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pf‐06447475 (pf‐475  (Millipore)

 
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    Structured Review

    Millipore pf‐06447475 (pf‐475
    The inhibition of LRRK2 by <t>PF‐475</t> and compound 4 promotes the proliferation of OPCs from rat brain cortices. (A) Representative images of OPCs cultures treated for 24 h with PF‐475 (0.1 μM) and 4 (1 and 5 μM) 6 h with BrdU, the number of BrdU + Olig2 + was measured. (B) Quantification of proliferating OPCs (BrdU + /Olig2 + double staining) was performed in respect to the total number of oligodendroglial cells (Olig2 + ) for LRRK2 inhibitors PF‐475 and compounds 1–5. Values represent the mean ± SEM of three replications in five different experiments. Results of Student's t ‐test are represented as: * p < 0.05 versus control. The scale bar represents 25 μm in A–D.
    Pf‐06447475 (Pf‐475, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pf‐06447475 (pf‐475/product/Millipore
    Average 90 stars, based on 1 article reviews
    pf‐06447475 (pf‐475 - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis"

    Article Title: Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis

    Journal: CNS Neuroscience & Therapeutics

    doi: 10.1111/cns.14552

    The inhibition of LRRK2 by PF‐475 and compound 4 promotes the proliferation of OPCs from rat brain cortices. (A) Representative images of OPCs cultures treated for 24 h with PF‐475 (0.1 μM) and 4 (1 and 5 μM) 6 h with BrdU, the number of BrdU + Olig2 + was measured. (B) Quantification of proliferating OPCs (BrdU + /Olig2 + double staining) was performed in respect to the total number of oligodendroglial cells (Olig2 + ) for LRRK2 inhibitors PF‐475 and compounds 1–5. Values represent the mean ± SEM of three replications in five different experiments. Results of Student's t ‐test are represented as: * p < 0.05 versus control. The scale bar represents 25 μm in A–D.
    Figure Legend Snippet: The inhibition of LRRK2 by PF‐475 and compound 4 promotes the proliferation of OPCs from rat brain cortices. (A) Representative images of OPCs cultures treated for 24 h with PF‐475 (0.1 μM) and 4 (1 and 5 μM) 6 h with BrdU, the number of BrdU + Olig2 + was measured. (B) Quantification of proliferating OPCs (BrdU + /Olig2 + double staining) was performed in respect to the total number of oligodendroglial cells (Olig2 + ) for LRRK2 inhibitors PF‐475 and compounds 1–5. Values represent the mean ± SEM of three replications in five different experiments. Results of Student's t ‐test are represented as: * p < 0.05 versus control. The scale bar represents 25 μm in A–D.

    Techniques Used: Inhibition, Double Staining



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    pf‐06447475 (pf‐475  (Millipore)
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    Millipore pf‐06447475 (pf‐475
    The inhibition of LRRK2 by <t>PF‐475</t> and compound 4 promotes the proliferation of OPCs from rat brain cortices. (A) Representative images of OPCs cultures treated for 24 h with PF‐475 (0.1 μM) and 4 (1 and 5 μM) 6 h with BrdU, the number of BrdU + Olig2 + was measured. (B) Quantification of proliferating OPCs (BrdU + /Olig2 + double staining) was performed in respect to the total number of oligodendroglial cells (Olig2 + ) for LRRK2 inhibitors PF‐475 and compounds 1–5. Values represent the mean ± SEM of three replications in five different experiments. Results of Student's t ‐test are represented as: * p < 0.05 versus control. The scale bar represents 25 μm in A–D.
    Pf‐06447475 (Pf‐475, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pf‐06447475 (pf‐475/product/Millipore
    Average 90 stars, based on 1 article reviews
    pf‐06447475 (pf‐475 - by Bioz Stars, 2026-03
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    Image Search Results


    The inhibition of LRRK2 by PF‐475 and compound 4 promotes the proliferation of OPCs from rat brain cortices. (A) Representative images of OPCs cultures treated for 24 h with PF‐475 (0.1 μM) and 4 (1 and 5 μM) 6 h with BrdU, the number of BrdU + Olig2 + was measured. (B) Quantification of proliferating OPCs (BrdU + /Olig2 + double staining) was performed in respect to the total number of oligodendroglial cells (Olig2 + ) for LRRK2 inhibitors PF‐475 and compounds 1–5. Values represent the mean ± SEM of three replications in five different experiments. Results of Student's t ‐test are represented as: * p < 0.05 versus control. The scale bar represents 25 μm in A–D.

    Journal: CNS Neuroscience & Therapeutics

    Article Title: Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis

    doi: 10.1111/cns.14552

    Figure Lengend Snippet: The inhibition of LRRK2 by PF‐475 and compound 4 promotes the proliferation of OPCs from rat brain cortices. (A) Representative images of OPCs cultures treated for 24 h with PF‐475 (0.1 μM) and 4 (1 and 5 μM) 6 h with BrdU, the number of BrdU + Olig2 + was measured. (B) Quantification of proliferating OPCs (BrdU + /Olig2 + double staining) was performed in respect to the total number of oligodendroglial cells (Olig2 + ) for LRRK2 inhibitors PF‐475 and compounds 1–5. Values represent the mean ± SEM of three replications in five different experiments. Results of Student's t ‐test are represented as: * p < 0.05 versus control. The scale bar represents 25 μm in A–D.

    Article Snippet: The inhibitor PF‐06447475 (PF‐475) was obtained from Sigma‐Aldrich.

    Techniques: Inhibition, Double Staining